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NIH summarizes evidence linking higher TMAO with cardiovascular risk, while also noting that the implications are not fully understood

specifically, Black/African American participation has been declining over the past decade including a 15% drop in 2017 from a 2013 peak of 12.3% and a 35% decrease in 20202021 from 9.8% to 6.5% Hispanic inclusiveness varied over the timeframe, ranging from 7.4% in 2015 to a high of 9.9% in 2017 Recent developments, including the drastic COVID outcome disparities seen in early 2020, along with a general racial reckoning in the U.S